The Group C rivals meet at the Stadio Olimpico to conclude the second half of their double header, having previously shared the points in a thrilling 3-3 Stamford Bridge draw on October 18.
Edin Dzeko and Eden Hazard scored two goals apiece in the six-goal spectacle, though both Eusebio Di Francesco and Antonio Conte will be keen on defensive improvements in Rome.
Chelsea currently top the group with seven points from three games, and can qualify for the last-16 with two games to spare if Atletico Madrid fail to beat Qarabag in the Spanish capital on Halloween.
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N’Golo Kante could return for Chelsea. The France midfielder has not played since the September 30 loss to Manchester City due to a hamstring injury.
Danny Drinkwater is also set to be included in the squad following a calf problem, with Victor Moses (hamstring) the only definite absentee.
Provisional squad: Courtois, Caballero, Rudiger, Alonso, Fabregas, Drinkwater, Kante, Morata, Hazard, Pedro, Bakayoko, Kenedy, Musonda, Zappacosta, Willian, Batshuayi, Cahill, Christensen, Azpilicueta, Luiz, Clarke-Salter, Scott, Eduardo.
Roma starting XI: Alisson; Bruno Peres, Juan Jesus, Fazio, Kolarov; De Rossi, Stfansitedbusrman, Nainggolan; Florenzi, Perotti, Dzeko
Chelsea starting XI: Courtois; Cahill, Luiz, Azpilicueta; Zappacosta, Fabregas, Bakayoko, Alonso; Pedro, Hazard, Morata
Head to head
Chelsea and Roma have now faced each other five times, with the Blues edging the results.
The 3-3 draw at Stamford Bridge was their second draw, with Chelsea beating the Italians twice and losing just once before – a 3-1 Champions League defeat at the Stadio Olimpico back in 2008.