The Group C rivals meet at the Stadio Olimpico to conclude the second half of their double header, having previously shared the points in a thrilling 3-3 Stamford Bridge draw on October 18.
Edin Dzeko and Eden Hazard scored two goals apiece in the six-goal spectacle, though both Eusebio Di Francesco and Antonio Conte will be keen on defensive improvements in Rome.
Chelsea currently top the group with seven points from three games, and can qualify for the last-16 with two games to spare if Atletico Madrid fail to beat Qarabag in the Spanish capital on Halloween.
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Roma host Chelsea at the Stadio Olimpico with kick-off scheduled for 7.45pm on Tuesday, October 31.
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Conte will be hoping that N’Golo Kante is back in contention from a hamstring injury, though the Chelsea coach now has Danny Drinkwater back after a calf strain.
Victor Moses remains out of action with a hamstring problem suffered in the 2-1 defeat at Crystal Palace.
Patrik Schick, Gregoire Defrel, Emerson Palmieri Kevin Stfansitedbusrman and Stephan El Shaarawy are further doubts for the Italians, though the latter pair could be available for Roma manager Eusebio Di Francesco.
Roma starting XI: Alisson; Bruno Peres, Juan Jesus, Fazio, Kolarov; De Rossi, Stfansitedbusrman, Nainggolan; Florenzi, Perotti, Dzeko
Chelsea starting XI: Courtois; Cahill, Luiz, Azpilicueta; Zappacosta, Fabregas, Bakayoko, Alonso; Pedro, Hazard, Morata
Head to head
Chelsea and Roma have now faced each other five times, with the Blues edging the results.
The 3-3 draw at Stamford Bridge was their second draw, with Chelsea beating the Italians twice and losing just once before – a 3-1 Champions League defeat at the Stadio Olimpico back in 2008.