Qarabag of Azerbaijan make their debut in the group stage, at the fourth attempt, after beating FC Copenhagen in the play-off round.
Antonio Conte has spoken at length for the need for increased numbers in his squad due to the extra commitments and will feel comfortable rotating his starting XI against the comparative minnows.
A shock defeat to Burnley a month ago has been followed by impressive wins over Tottenham, Everton and, most recently, Leicester City. Another should follow in midweek.
Scroll down for Standard Sport’s comprehensive preview…
Chelsea host Qarabag at Stamford Bridge on Tuesday, September 12, with kick-off scheduled for 19.45 BST.
TV and live online coverage
The game will be televised live in the UK on BT Sport//ESPN, with coverage starting at 7pm. Alternatively, you can follow live updates with Standard Sport’s blog.
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Antonio Conte will likely rotate his squad for the visit of the European minnows.
Eden Hazard played his first domestic minutes of the season when coming on as a substitute against Leicester and could be afforded a start on Tuesday.
Elsewhere, new signings Davide Zappacosta, Danny Drinkwater and Willy Caballero could all feature, while Willian will be looking for a return to the starting XI after dropping out at the weekend.
Qarabag will likely line up in a 4-1-4-1 formation, with former Birmingham City midfielder Michel in midfield and Dino Ndlovu leading the line.
Predicted Chelsea XI: Caballero; Rudiger, Cahill, Christiansen; Zappacosta, Drinkwater, Kante, Alonso; Willian, Batshuayi, Hazard
Predicted Qarabag XI: Sehic; Medvedev, Rzezniczak, Huseynov, Agolli; Qarayev; Guerrier, Michel, Almeida, Madatov; Ndlovu
Head to head
Chelsea and Qarabag have never played each other in a competitive game.
Bettings odds (via betfair)
- Chelsea to win: 1/10
- Draw: 9/1
- Qarabag to win: 33/1
Click here to place a bet. Odds correct as of September 10 at 6pm.