The Chelsea defender was back in action at Under-23 level earlier this week following an eight-month spell on the sidelines with a knee injury.
And he will feature again for the Blues’ reserve team, this time against Everton on Monday, before being considered by Conte.
“Zouma played a game with the Under-23s and the physical answer was good”
Chelsea boss Antonio Conte
“Zouma played a game with the Under-23s and the physical answer was good,” Conte said at his pre-match press conference.
“Now we prefer him to play another game on Monday and if it’s all okay he will come back to us.
“I am very happy because I can have another central defender and a good central defender, a young one with great potential.”
Cesc Fabregas has missed the last three fixtures with a thigh injury and will not make the trip to Southampton.
“Fabregas stayed with us in a part of the training session on Friday, when we tried offensive movements, and I think he will be ready next week,” Conte said.
Conte can call on defender Branislav Ivanovic, who is available following a two-week absence.