Terry made his first start in more than six weeks following an ankle injury as the Blues made seven changes for Wednesday’s EFL Cup loss at West Ham.
But Antonio Conte is likely to recall many of the players involved in last Sunday’s comprehensive win over Manchester United.
Defender Branislav Ivanovic is available and Kurt Zouma is nearing a return from his long-term knee injury, while playmaker Cesc Fabregas (thigh) remains out.
Southampton defender Ryan Bertrand could return from a hamstring injury for the visit of his former club.
But Jay Rodriguez is a doubt after going off following a clash of heads during Wednesday’s EFL Cup win over Sunderland and fellow striker Shane Long is still out with a hamstring problem.
Fraser Forster, Virgil van Dijk, Steven Davis and Charlie Austin will be among the players who return after being rested against the Black Cats.
Southampton squad: Forster, McCarthy, Soares, Targett, Bertrand, Martina, Yoshida, Fonte, Van Dijk, McQueen, Stephens, Hojbjerg, Romeu, Ward-Prowse, Clasie, Reed, Tadic, Boufal, Davis, Redmond, Rodriguez, Austin.
Chelsea squad: Courtois, Begovic, Ivanovic, Alonso, Kante, Oscar, Hazard, Pedro, Mikel, Loftus-Cheek, Moses, Costa, Matic, Willian, Batshuayi, Cahill, Terry, Azpilicueta, Chalobah, Luiz, Eduardo, Aina, Solanke.