Chris Smalling and Daley Blind’s future is in severe doubt with Mourinho targeting a centre-back and right-back in January.
United will also consider selling Marcos Rojo and Matteo Darmian in the transfer window, while Luke Shaw is yet to convince Mourinho.
“Man United boss Jose Mourinho is ready to shake things up at Old Trafford”
The Special One is keen to bring in a natural right-back to give makeshift defender Antonio Valencia competition.
The Mail reckon work has already begun behind the scenes to identify reinforcements, with Roma defender Antonio Rudiger under consideration.
The German international, 23, is also on Chelsea‘s radar and will be watched on a regular basis by United scouts.
Roma are desperate to keep hold of their star man but an offer of £35m would seriously tempt the Serie A giants.
One defender safe at Old Trafford is summer signing Eric Bailly.
The Ivory Coast international has impressed Mourinho since his £30m move prior to picking up a knee ligament injury against Chelsea last weekend.
United host Burnley tomorrow as Mourinho’s men look to get their Premier League season back on track.