Antonio Conte’s side head into the clash with an eight-point lead at the top of the table having won their last two league games.
Liverpool, on the other hand, have failed to secure three points in 2017.
“I think the only thing guaranteed at Anfield is both sides finding the back of the net”
Jurgen Klopp’s side also flopped out of the FA Cup on to Championship side Wolves and lost to Southampton in the EFL Cup semi-final.
But they are boosted by the return from international duty of Sadio Mane, who starts on the bench.
Owen told BetVictor: “Wolves produced the shock of the fourth round, knocking Liverpool out of the FA Cup with a 3-2 win at Anfield prompting Reds boss Jurgen Klopp to apologise to fans afterwards.
“Liverpool have struggled to replicate the industry shown by Saido Mane in the final third of the field, and the Reds will need to be at their best to beat a Chelsea side that are now as short as 2/5 with BetVictor to be crowned Champions in May.
“Klopp has a wonderful record against other sides in the ‘big six’ since taking over from Brendan Rodgers, losing just 1 of 14 PL games, and I think the only thing guaranteed at Anfield is both sides finding the back of the net.”