Mignolet came in to keep a clean sheet in the 3-0 romp at Middlesbrough – his first Premier League appearance for three months.
Klopp insists he wasn’t swayed by criticism of the 23-year-old by pundits Phil and Gary Neville.
And while Mignolet is relishing the chance to re-establish himself as No.1 after being dislodged by Karius he insists his rival will overcome the blow of losing his place.
“He knows that you have to just stay focused, keep your head down and work hard”
Simon Mignolet on Loris Karius
“It’s not nice for Loris but he’s capable enough and professional enough to learn from it,” said Mignolet.
“He’s a team-mate so of course I have sympathy for him, but we both know that no one individual is bigger than the team.
“At a club as big as Liverpool you have to be mentally strong because one mistake can be blown out of proportion. I’ve been through it, and it’s not nice.
“He knows that you have to just stay focused, keep your head down and work hard. It’s not always easy but you have to wait for your opportunity.”
Mignolet had chance to commiserate with Karius when they joined up with Liverpool’s goalkeeping staff for their annual Christmas dinner on Thursday.
The Belgium international added: “The keepers’ union is something special. Only if you’re a keeper do you know what it’s like to be in our situation.
“Loris and I are team-mates, but we have to push each other and look out for our own performances.”
Mignolet kept his third clean sheet of the season as Liverpool won for the first time on Teesside for 14 years to climb to second in the table and ease the pain of dropping five points against the Cherries and the Hammers.
The 28-year-old was added: “It was a satisfying clean sheet but the most important thing was the three points because we know that when results are not there we’ll always get criticised.
“It was an important win after a couple of rough weeks.”