The Blues winger picked up a knock in the 1-0 win against West Brom and did not travel with the squad to Wearside.
It is a major blow for Antonio Conte, who is hoping to make it 10 wins on the bounce and extend Chelsea‘s lead at the top of the table to six points.
Hazard has been in fine form this season, contributing eight goals and one assist in 15 appearances.
“Eden Hazard picked up a knock in the 1-0 win against West Brom”
He is expected to return to fitness for the weekend trip to Crystal Palace.
Willian should replace Hazard in Conte’s starting XI against the Black Cats tonight.
The Brazil international has barely figured in recent weeks due to injury and the death of his mother.
He is raring to return and said: “I feel more fresh and good to come back in the team.
“[Conte] gives me confidence to get back in the team and train hard to play well.
“I am happy because I came in and helped my team-mates to win that game [against Man City].
“Sometimes the game is asking to change some things, to put in another player and change the system.
“The players on the bench have to be focused because, when you go in, you have to do something different.”