The Blues have been in scintillating form in recent weeks, winning nine consecutive matches to go three points clear at the top of the table.
Antonio Conte and co face a Sunderland side currently bottom at the Stadium of Light tomorrow and Merson believes they will only be one outcome.
He told Sky Sports: “Didier Ndong will be a miss for Sunderland through suspension as he is the engine in their team.
“They had a shocking result against Swansea and I can’t see anything other than a Chelsea win.
“Paul Merson ,Chelsea ,Sunderland ,Crystal Palace, Manchester United ,Premier League,Sunderland v Chelsea,Crystal Palace v Manchester United,”
“Chelsea are having to work hard for their wins and West Brom were a bit unlucky not to get anything at the weekend.
“But Chelsea have champagne moments in their team and they are rock solid at the back.”
After they take on Sunderland, Chelsea make the trip to Crystal Palace on Saturday.
Alan Pardew’s men are currently just three points clear of the relegation zone and face Manchester United tomorrow evening.
Palace have only won once in their last nine league outings and Merson reckons they will come up short against Jose Mourinho’s Red Devils.
He said: “I have been impressed with United. They have really turned the corner, they haven’t had much luck but they got a good result against Spurs and they look decent.
“Henrikh Mkhitaryan will be missed, that is a major blow, because they are a lot better when he is in the team, they move the ball quicker and have more of a threat.
“Palace, though, are letting in goals for fun.
“To give them their due, it’s open and attacking football, and they were unlucky the other day with that Robert Snodgrass penalty which was bordering on ridiculous.
“Wilfried Zaha has looked outstanding recently, I can’t remember the last time he had a bad game, but they are playing his way.”